A cardiopulmonary study of lisdexamfetamine in adults with attention-deficit/hyperactivity disorder

The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry
Paul HammernessTimothy Wilens

Abstract

Due to concerns about the safety of stimulants for ADHD, novel assessments of the cardiopulmonary impact of these agents are needed. An open design of lisdexamfetamine (LDX) in 15 adults with DSM-IV ADHD. Following a psychiatric evaluation and medical history, subjects underwent echocardiography (TTE) and cardiopulmonary exercise testing (CPET). LDX was titrated to 70 mg daily over 6 weeks, followed by monthly visits to 6 months. Change in TTE and CPET measures were examined following up to 6 months of LDX. At endpoint, there were no significant alterations in indices of cardiac systolic performance, or in metabolic and ventilatory variables at maximum exertion (P values >0.05). We found significant mean changes in resting LV systolic dimension and Doppler diastolic indices. Change in heart rate recovery at 1 min met statistical significance (P = 0.05). We did not detect clinically meaningful changes in cardiac structure and function or in metabolic and ventilatory variables at maximum exertion in ADHD adults receiving open LDX. The clinical significance of changes in resting LV dimension and indices of diastolic function are not in the direction of cardiomyopathy. Future large sample controlled study can examine these findings...Continue Reading

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Citations

Jun 24, 2011·Current Psychiatry Reports·Paul G HammernessAshley Chilton
May 3, 2014·CNS Drugs·David R CoghillRichard Civil
Feb 5, 2015·Expert Opinion on Drug Safety·Paul G HammernessMark E Alexander
Apr 7, 2016·CNS Drugs·James E Frampton
Jul 17, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Eric MickRobert J Goldberg
Sep 15, 2016·Journal of Child and Adolescent Psychopharmacology·Arthur N WestoverEthan A Halm
Sep 1, 2017·Journal of Central Nervous System Disease·Jadwiga NajibAnu Thadavila
Mar 19, 2016·Journal of Clinical Psychopharmacology·Arthur N WestoverLaura F DeFina
Apr 3, 2021·The American Journal of Drug and Alcohol Abuse·John J MarianiFrances R Levin

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