A carotenoid synthesis gene cluster from Algoriphagus sp. KK10202C with a novel fusion-type lycopene beta-cyclase gene.

Molecular Genetics and Genomics : MGG
Luan TaoQiong Cheng

Abstract

A carotenoid synthesis gene cluster was isolated from a marine bacterium Algoriphagus sp. strain KK10202C that synthesized flexixanthin. Seven genes were transcribed in the same direction, among which five of them were involved in carotenoid synthesis. This cluster had a unique gene organization, with an isoprenoid gene, ispH (previously named lytB), being present among the carotenoid synthesis genes. The lycopene beta-cyclase encoded by the crtY ( cd ) gene appeared to be a fusion of bacterial heterodimeric lycopene cyclase CrtY(c) and CrtY(d). This was the first time that a fusion-type of lycopene beta-cyclase was reported in eubacteria. Heterologous expression of the Algoriphagus crtY ( cd ) gene in lycopene-accumulating Escherichia coli produced bicyclic beta-carotene. A biosynthesis pathway for monocyclic flexixanthin was proposed in Algoriphagus sp. strain KK10202C, though several of the carotenoid synthesis genes not linked with the cluster have not yet been cloned.

References

Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Jan 1, 1966·Acta Chemica Scandinavica·A J Aasen, S L Jensen
Sep 1, 1995·The Plant Journal : for Cell and Molecular Biology·P HugueneyM Kuntz
May 1, 1996·The Biochemical Journal·G SchnurrG Sandmann
Sep 27, 2000·Journal of Bacteriology·F X CunninghamE Gantt
Feb 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·N ArrachJ Avalos
Jan 31, 2002·Proceedings of the National Academy of Sciences of the United States of America·Felix RohdichWolfgang Eisenreich
Feb 28, 2002·Molecular Genetics and Genomics : MGG·N ArrachJ Avalos
May 24, 2003·Biochemical and Biophysical Research Communications·Hisashi HemmiTokuzo Nishino
Jan 22, 2004·The Journal of Biological Chemistry·Eric GiraudAndre Verméglio
Jan 24, 2004·Molecular Genetics and Genomics : MGG·L TaoQ Cheng
Jun 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·O FüttererW Liebl
Jul 21, 2004·Briefings in Bioinformatics·Sudhir KumarMasatoshi Nei
Jul 1, 1985·Evolution; International Journal of Organic Evolution·Joseph Felsenstein

❮ Previous
Next ❯

Citations

Feb 22, 2012·Analytical and Bioanalytical Chemistry·Lewis R DartnellHowell G M Edwards
Apr 26, 2008·Applied Microbiology and Biotechnology·Antonio A IniestaFrancisco J Murillo
Feb 12, 2008·Applied and Environmental Microbiology·Jonathan L Klassen, Julia M Foght
Jun 5, 2008·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Yue-Hui ZhuQian Chen
Mar 26, 2014·Marine Drugs·Kazutoshi Shindo, Norihiko Misawa
Mar 1, 2012·International Journal of Systematic and Evolutionary Microbiology·Rosanna A AlegadoNicole King
Nov 10, 2010·Natural Product Reports·Haoran ZhangBlaine A Pfeifer
Oct 11, 2019·Environmental Microbiology Reports·Nicolai KallscheuerOlga M Lage
Feb 26, 2021·Archives of Microbiology·Dan-Dan ShangZong-Jun Du
May 15, 2021·Microbial Ecology·Gonçalo FigueiredoTânia Caetano
Oct 20, 2020·Journal of Agricultural and Food Chemistry·Zilong ZhaoXiangzhao Mao
Oct 12, 2021·International Journal of Systematic and Evolutionary Microbiology·Di LiuGuishan Zhang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.