A cascade Claisen rearrangement/o-quinone methide formation/electrocyclization approach to 2H-chromenes

Chemical Communications : Chem Comm
Liyan SongRongbiao Tong

Abstract

A new approach has been developed for the synthesis of 8-substituted 2H-chromenes, featuring a novel cascade aromatic Claisen rearrangement/o-quinone methide formation/6π-electrocyclization. This new method was demonstrated with 28 examples tolerating different substitutions at alkenes, allylic and aromatic ring and with total syntheses of three 2H-chromene natural products.

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Citations

Jul 3, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Benedicta AssoahNuno R Candeias
Oct 25, 2017·Organic Letters·Hai Huang, Jun Yong Kang
Nov 30, 2021·Organic & Biomolecular Chemistry·Shi-Lu Zheng, Long Chen

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Fortschritte der Chemie organischer Naturstoffe = Progress in the chemistry of organic natural products. Progrès dans la chimie des substances organiques naturelles
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