A case-control analysis of nonsteroidal anti-inflammatory drugs and Alzheimer's disease: are they protective?

Neuroepidemiology
C WolfsonF Momoli

Abstract

In many studies of nonsteroidal anti-inflammatory drugs (NSAIDs) and Alzheimer's disease (AD), the exposure to NSAIDs was concurrent with AD or based on self (or surrogate) report. We conducted a case-control analysis of the Québec participants in the Canadian Study of Health and Aging who received a diagnosis of AD (cases) or were found to be cognitively unimpaired on screening (controls). Information on drug use was obtained from the Québec Provincial Pharmaceutical Services Database. There was no significant difference in the proportion of cases and controls who had received any NSAID prescriptions in the 3 years prior to the onset of symptoms of dementia; amongst NSAID users, there was no difference in mean dose or duration. Our findings, using a measure of drug use prior to symptom onset and not subject to recall bias, do not support a protective effect for NSAIDs.

Citations

Sep 21, 2013·Acta Neuropathologica·Patrick L McGeer, Edith G McGeer
Aug 26, 2006·Journal of Neural Transmission·Y I Arshavsky
Apr 27, 2012·Inflammopharmacology·G Joseph BroussardGloria J Klapstein
Aug 19, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Edith G McGeer, Patrick L McGeer
Feb 9, 2012·Cold Spring Harbor Perspectives in Medicine·Tony Wyss-Coray, Joseph Rogers
Jul 29, 2004·Neuroepidemiology·Christine A SzekelySteven N Goodman
Aug 28, 2010·International Journal of Alzheimer's Disease·Daniela L Krause, Norbert Müller
Apr 28, 2005·Expert Review of Neurotherapeutics·Sally Walsh, Paul S Aisen
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Oct 1, 2007·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·David B HoganLilian Thorpe
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May 16, 2006·Neurobiology of Aging·Patrick L McGeer, Edith G McGeer
Jan 29, 2020·Journal of Biomedical Science·Yoshihito HayashiKuen-Jer Tsai

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