A case control study of chorioamniotic infection and histological chorioamnionitis in stillbirth

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
E FolgosaA Ljungh

Abstract

In order to elucidate the role and aetiology of chorioamnionitis in stillbirth a case referent study was carried out in 58 pregnant women with late foetal death (cases) and in 58 pregnant women at term with live foetus (referents) matched for age and parity in Maputo Mozambique. Samples from women, stillborns and liveborns, were collected for microbiological and histological assessment. Histological chorioamnionitis was diagnosed in 96% of the cases and in 67% of the referents (OR = 13.5; 95% CI: 2.9-123.9). Escherichia coli was the species most frequently isolated in stillborns; in 14/16 (88%) cases it was isolated from intracardiac fluid. E. coli was associated with chorioamnionitis in 28% of the stillborns as compared to 5% of the referents (OR = 6.9; 95% CI: 1.4-65.4). No group B streptococci were recovered from any placenta or newborn. Vasculitis was present in 12 (21%) cases and in 3 (5%) referents (OR = 4.8; 95%, CI: 1.2-27.7). Histological chorioamnionitis was thus associated with stillbirth. E. coli was common in stillborns. The presence of vasculitis in one fifth of the stillborns indicated that the foetus was alive at the onset of infection.

References

Jul 3, 1975·The New England Journal of Medicine·R L Naeye
Mar 1, 1990·The Journal of Infectious Diseases·B ElliottF A Plummer
Oct 13, 1988·The New England Journal of Medicine·S L HillierD A Eschenbach
Jun 28, 1985·The American Journal of Medicine·J A Washington
Jan 1, 1993·Annals of Epidemiology·M A KrohnD A Eschenbach
Dec 1, 1995·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·S R MoyoA Ljungh
Aug 1, 1996·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·S R MoyoA Ljungh

❮ Previous
Next ❯

Citations

Jun 5, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·F MwanyumbaM Temmerman
Apr 16, 2002·Acta Obstetricia Et Gynecologica Scandinavica·Siri VangenBabill Stray-Pedersen
Aug 9, 2002·Tropical Medicine & International Health : TM & IH·Kenneth ChallisStaffan Bergström
Mar 13, 2010·Lancet·Robert L GoldenbergUma M Reddy
Mar 17, 2009·Seminars in Fetal & Neonatal Medicine·Elizabeth M McClure, Robert L Goldenberg
Jul 17, 2015·BJOG : an International Journal of Obstetrics and Gynaecology·C NanM C Cunnington
Jan 24, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ingela Hulthén VarliKarin Petersson
Mar 10, 2007·American Journal of Obstetrics and Gynecology·Monica M LahraHeather E Jeffery
Oct 4, 2003·American Journal of Obstetrics and Gynecology·Robert L Goldenberg, Cortney Thompson
Sep 16, 2016·Journal of Perinatology : Official Journal of the California Perinatal Association·G J ChanT K Boyd
Jul 16, 2004·Journal of Perinatology : Official Journal of the California Perinatal Association·Gulsum Akdag AtayDerya Aysev
Nov 9, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anna C SealeShabir A Madhi
Apr 3, 2020·Journal of Perinatal Medicine·Sunil JaimanChaur-Dong Hsu
Apr 16, 2002·Acta Obstetricia Et Gynecologica Scandinavica·Karin PeterssonKerstin Wolff
Mar 1, 2017·Research in Microbiology·Piet Cools
Apr 25, 2017·Research in Microbiology·Piet Cools, Pierrette Melin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.