PMID: 8605110Mar 1, 1996Paper

A case-control study of cryptorchidism and maternal hormone concentrations in early pregnancy

British Journal of Cancer
T J KeyM C Pike

Abstract

Serum samples taken between 6 and 20 weeks of gestation were obtained from 28 mothers who gave birth to cryptorchid sons (cases) and from 108 control mothers. In comparison with controls the cases had 10% higher geometric mean oestradiol (95% CI -13% to +39%: P=0.42) and 10% lower geometric mean testosterone (95% CI -27% to +10%: P=0.30). Among the samples collected between 6 and 14 weeks of gestation geometric mean concentrations of oestradiol and testosterone were 5% lower (95% CI -32% to +31%: P=0.74) and 25% lower (95% CI -45% to +1%: P=0.06) respectively in cases than in controls. Among the samples collected between 15 and 20 weeks of gestation geometric mean concentrations of oestradiol and testosterone were 29% higher (95% CI -8% to +79%: P=0.14) and 21% higher (95% CI -8% to +60%: P=0.18) respectively in cases than in controls. The results do not support the hypothesis that cryptorchidism may be caused by high concentrations of oestradiol in the maternal blood during the first phase of testicular descent, but suggest that the possible association of cryptorchidism with low maternal testosterone during early gestation should be further investigated.

Citations

Aug 20, 2009·Environmental Health : a Global Access Science Source·Julie R PalmerRobert N Hoover
Jun 15, 2000·Environmental Health Perspectives·J L PryorB Robaire
Feb 22, 2008·Environmental Health Perspectives·Olwenn V MartinNikolaos Voulvoulis
Nov 12, 2009·Future Oncology·Katherine A McGlynn, Michael B Cook
Mar 1, 2000·Medical and Pediatric Oncology·J U CopeM A Tucker
Oct 12, 2000·Nature·M H Wang, F S vom Saal
Mar 28, 2008·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Michael GarnerMichael Wade
Apr 13, 2012·Prenatal Diagnosis·Stefan F NemecDaniela Prayer
Sep 25, 2008·Ciência & saúde coletiva·Olwenn MartinNikolaos Voulvoulis
Nov 23, 2006·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Mihi YangHo Sun Lee
Dec 5, 2006·Journal of Perinatal Medicine·Jin Ho ChongDaisy Kwai Lin Chan
Jun 28, 2017·Nature Reviews. Urology·Jason K GurneyDiana Sarfati
Oct 8, 2005·Environmental Research·Parvathi K Basrur

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