A case-control study of maternal periconceptual and pregnancy recreational drug use and fetal malformation using hair analysis

PloS One
Anna L DavidL S Chitty

Abstract

Maternal recreational drug use may be associated with the development of fetal malformations such as gastroschisis, brain and limb defects, the aetiology due to vascular disruption during organogenesis. Using forensic hair analysis we reported evidence of recreational drug use in 18% of women with a fetal gastroschisis. Here we investigate this association in a variety of fetal malformations using the same method. In a multi-centre study, women with normal pregnancies (controls) and those with fetal abnormalities (cases) gave informed consent for hair analysis for recreational drug metabolites using mass spectrometry. Hair samples cut at the root were tested in sections corresponding to 3 month time periods (pre and periconceptual period). Women whose fetus had gastroschisis, compared to women with a normal control fetus, were younger (mean age 23.78 ± SD4.79 years, 18-37 vs 29.79 ± SD6 years, 18-42, p = 0.00001), were more likely to have evidence of recreational drug use (15, 25.4% vs 21, 13%, OR2.27, 95thCI 1.08-4.78, p = 0.028), and were less likely to report periconceptual folic acid use (31, 53.4% vs 124, 77.5%, OR0.33, 95thCI 0.18-0.63, p = 0.001). Age-matched normal control women were no less likely to test positive for ...Continue Reading

References

Jun 1, 1991·American Journal of Diseases of Children·R DominguezT P Bohan
Jan 1, 1991·The Journal of Pediatrics·S E LipshultzE J Orav
Mar 1, 1970·European Journal of Pharmacology·E DolfiniL Valzelli
Oct 1, 1982·Teratology·J Franz, J Kleinebrecht
Mar 1, 1994·Clinical Pediatrics·J HoF B Stapleton
Mar 1, 1997·American Journal of Public Health·J KlineM Susser
Apr 21, 1998·Obstetrics and Gynecology Clinics of North America·M A Plessinger
Feb 26, 2000·Forensic Science International : Synergy·V Spiehler
Feb 26, 2000·Forensic Science International : Synergy·J KleinG Koren
Jul 17, 2001·Annals of Epidemiology·T H BeatyI McIntosh
Sep 5, 2002·Forensic Science International : Synergy·Marilyn A Huestis, Robin E Choo
Nov 28, 2002·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A OrricoG Hayek
Jan 28, 2004·Birth Defects Research. Part A, Clinical and Molecular Teratology·Maki KashiwagiGundula Hebisch
Dec 4, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Marion VillainPascal Kintz
Jul 28, 2005·BJOG : an International Journal of Obstetrics and Gynaecology·John J MorrisonCharles H Rodeck
Jun 28, 2006·Australian and New Zealand Journal of Public Health·Carol BowerPeta Serna
Dec 8, 2007·American Journal of Epidemiology·Elizabeth S DraperJennifer J Kurinczuk
Jul 17, 2012·International Journal of Epidemiology·Shantini ParanjothyStephen R Palmer
Aug 6, 2013·Birth Defects Research. Part A, Clinical and Molecular Teratology·Tanya BedardJohn D Dyck
Nov 26, 2013·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·H Cuckle

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Citations

Feb 9, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Jean R GoodmanAndrew Elimian
Feb 14, 2020·Archives of Disease in Childhood·Silvia BaldacciAnna Pierini
Mar 19, 2020·Journal of Addiction Medicine·Albert Stuart Reece, Gary Kenneth Hulse
Dec 8, 2020·Journal of Developmental Origins of Health and Disease·Oyekoya T AyonrindeOyekunle K Ayonrinde
Jul 29, 2021·BMC Pregnancy and Childbirth·Beth McDougallSara L White

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

SPSS PASW Statistics

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