A case-control study of response to lamivudine therapy for 2 years in Japanese and Chinese patients chronically infected with hepatitis B virus of genotypes Bj, Ba and C

Hepatology Research : the Official Journal of the Japan Society of Hepatology
Etsuro OritoMasashi Mizokami

Abstract

In eastern Asian countries, hepatitis B virus (HBV) genotype Ba (HBV/Ba), HBV/Bj and HBV/C are prevalent. The aim was to investigate the response or resistance to lamivudine therapy among patients with different HBV genotypes. Of 67 Japanese and Chinese patients with chronic hepatitis B, 18 patients with HBV/Bj, 15 with HBV/Ba and 34 with HBV/C were selected for a case-control study matched according to gender and age. All the patients were treated with lamivudine for 2 years and evaluated the response or emergence of the YMDD mutation at year 2 during the treatment. HBV genotypes were detected by the restriction fragment length polymorphism. The YMDD mutation was detected by the direct sequencing after amplification by PCR. At year 2 during therapy, 44.8% of the patients showed normalization of ALT and undetectable HBV DNA (favorable response), 35.8% developed the YMDD mutation. There was no significant difference of response to the therapy among the three genotype groups. The emergence of the YMDD mutation was associated with HBV/C. By the multiple logistic regression analysis, however, the significant factor of a favorable response was a higher pretreatment ALT level and negative HBeAg status and the significant factor of th...Continue Reading

References

Dec 11, 1997·The New England Journal of Medicine·W M Lee
Jun 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K ChayamaH Kumada
Jul 9, 1998·The New England Journal of Medicine·C L LaiD F Gray
Mar 3, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H L ChanA S Lok
Sep 26, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D T LauJ H Hoofnagle
Dec 22, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E OritoS Iino
Aug 30, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E OritoM Mizokami
Jun 27, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Robert P PerrilloStephen D Gardner
Jul 19, 2002·The Journal of General Virology·Patricia Arauz-RuizLars O Magnius
Oct 28, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rong-Nan ChienYun-Fan Liaw
Dec 23, 2003·Intervirology·Yuzo Miyakawa, Masashi Mizokami
Jan 31, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Bernhard ZöllnerHeinz-Hubert Feucht
Jul 6, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Chung Mau LoJohn Wong

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Citations

Apr 16, 2008·Journal of Gastroenterology and Hepatology·Koichiro KusumotoKatsumi Eguchi
Dec 24, 2013·BioMed Research International·Xiu-Li ChenXiao-Lan Zhang
May 3, 2008·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Mari Inada, Osamu Yokosuka
Apr 19, 2012·Memórias do Instituto Oswaldo Cruz·Francisco Campello do Amaral MelloSelma de Andrade Gomes

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