A case-control study of risk factors associated with human T-cell lymphotrophic virus type-I seropositivity in blood donors from Guadeloupe, French West Indies

Vox Sanguinis
F RouetM Strobel

Abstract

An age- and gender-specific distribution characterizes human T-cell lymphotrophic virus type-I (HTLV-I) seropositivity in Guadeloupe (French West Indies). Further epidemiological studies are required to identify other possible risk factors associated with this retroviral infection. A nested case-control study was conducted between 1997 and 1999 among blood donors. A total of 102 HTLV-I-positive subjects were matched (at a ratio of 1 : 3) by gender, age (+/-5 years) and donor status (new or regular) to 306 HTLV-I-negative controls. Information was obtained through a questionnaire assessing both environmental and behavioural variables. Factors independently associated with HTLV-I infection included a low level of education [odds ratio (OR) 6.61, confidence interval (CI) 2.89-15.15], black ethnicity (OR 3.28, CI 1.01-10.65), two or more sex partners in the previous 3 years (OR 2.43, CI 1.16-5.10), early age at first sexual intercourse (0.84 risk reduction per additional year, CI 0.76-0.93), a history of sexually transmitted diseases (OR 2.29, CI 1.0-5.34) and positive Chlamydia serology (OR 1.95, CI 1.03-3.68). These data provide a wide spectrum of features associated with HTLV-I seropositivity, especially sexual risk factors. It ...Continue Reading

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Citations

Aug 16, 2011·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Houshang RafatpanahAli Bazarbachi
Apr 18, 2013·PLoS Pathogens·Nicolas A GilletCharles R M Bangham
Jul 23, 2013·PLoS Neglected Tropical Diseases·Fabian SchärPeter Odermatt
Dec 19, 2014·PLoS Neglected Tropical Diseases·Camila F AmorimEdgar M Carvalho
Dec 6, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Inês DouradoBernardo Galvão-Castro
May 9, 2007·Revista Da Sociedade Brasileira De Medicina Tropical·Ivanoska MoxotoBernardo Galvão-Castro

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