A case-control study of selenoprotein genes polymorphisms and autoimmune thyroid diseases in a Chinese population

BMC Medical Genetics
Ling XiaoJin-An Zhang

Abstract

Selenium is an essential trace and there is a high selenium concentration in the thyroid gland. Selenium deficiency may impair the thyroid function. The aim of this study was to investigate the association between three selenoprotein genes polymorphisms and autoimmune thyroid diseases. We genotyped six single-nucleotide polymorphisms (SNPs), rs6865453 in selenoprotein P gene (SELENOP), rs713041 rs2074451 rs3746165 in glutathione peroxidase 4 gene (GPX4) and rs28665122 and rs7178239 in selenoprotein S gene (SELENOS) by MassARRAY system using the chip-based matrix-assisted laser desorption ionization time-of-flight mass spectrometry technology in 1060 patients with autoimmune thyroid diseases and 938 healthy controls. Major alleles in rs6865453 of SELENOP, rs713041, rs2074451, rs3746165 of GPX4 decreased while the major allele C in rs28665122 of SELENOS increased in AITD patients than in the control. The allele C and genotype CC in rs7178239 of SELENOS showed different trend in GD and HT patients when compared with the control. All the distribution difference showed nonsignificant. Analysis according to clinical features including ophthalmopathy, hypothyroidism and family history came out to be negative either. Our findings sugge...Continue Reading

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Citations

Jun 7, 2018·Hormones : International Journal of Endocrinology and Metabolism·Ana Valea, Carmen Emanuela Georgescu
Jun 27, 2019·Biological Trace Element Research·Huimin Ying, Yan Zhang
Nov 8, 2020·Antioxidants·Christina ThanasGerasimos P Sykiotis

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Methods Mentioned

BETA
genotyping
Assay
chip

Software Mentioned

MassARRAY workstation
GraphPad Prism
SPSS22
Assay Designer
HWE
Sequenom TYPER

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