A case-control study of trace-element status and lung cancer in Appalachian Kentucky

PloS One
Jason M UnrineSusanne M Arnold

Abstract

Appalachian Kentucky (App KY) leads the nation in lung cancer incidence and mortality. Trace elements, such as As, have been associated with lung cancers in other regions of the country and we hypothesized that a population-based study would reveal higher trace element concentrations in App KY individuals with cancer compared to controls. Using toenail and drinking water trace element concentrations, this study investigated a possible association between lung cancer incidence and trace-element exposure in residents of this region. This population-based case-control study had 520 subjects, and 367 subjects provided toenail samples. Additionally, we explored the relationship between toenail and fingernail trace-element concentrations to determine if fingernails could be used as a surrogate for toenails when patients are unable to provide toenail samples. We found that, contrary to our initial hypothesis, trace element concentrations (Al, As, Cr, Mn, Co, Fe, Ni, Cu, Se, and Pb) were not higher in cancer cases than controls with the exception of Zn where concentrations were slightly higher in cases. In fact, univariate logistic regression models showed that individuals with lower concentrations of several elements (Al, Mn, Cr, and ...Continue Reading

References

Jul 1, 1990·American Journal of Epidemiology·D J HunterW C Willett
Jan 1, 1994·Environmental Health Perspectives·H M Shen, Q F Zhang
May 1, 1996·American Journal of Industrial Medicine·K SteenlandN Simonsen
Oct 1, 1996·American Journal of Epidemiology·M GarlandD J Hunter
Apr 15, 1997·Biochemistry·C M Davis, J B Vincent
May 1, 1997·Cancer Causes & Control : CCC·R B Hayes
Oct 3, 1998·International Journal of Epidemiology·C Hopenhayn-RichA H Smith
May 4, 2001·Journal of Chromatography. B, Biomedical Sciences and Applications·G N Mahoney, W Al-Delaimy
Feb 8, 2003·Environmental Health Perspectives·Andrea L HinwoodOlaf H Drummer
Jun 24, 2005·American Journal of Epidemiology·Eliseo GuallarUNKNOWN EURAMIC-Heavy Metals and Myocardial Infraction Study Group
Jan 31, 2006·Environmental Research·Melissa J Slotnick, Jerome O Nriagu
Mar 17, 2007·Journal of Toxicology and Environmental Health. Part a·Melissa J SlotnickJerome O Nriagu
Jun 24, 2008·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Richard Y Wang
Nov 4, 2008·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Melissa J SlotnickJerome O Nriagu
Sep 12, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·S YaemsiriK He
Jan 6, 2010·Environmental Health Perspectives·Julia E HeckEric J Duell
May 11, 2010·Amino Acids·Aaron K HolleyDaret K St Clair
Dec 1, 2011·Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer·Nancy JohnsonLi Li
Dec 21, 2011·Gut·André F S AmaralNúria Malats
Apr 30, 2013·International Journal of Hygiene and Environmental Health·Wesu NdililaAndrea L Hinwood
Jan 1, 2014·Journal of Occupational and Environmental Hygiene·Rachel GrashowJennifer M Cavallari
Sep 19, 2014·Biological Trace Element Research·Muhammad Abdul Qayyum, Munir H Shah
Mar 18, 2015·American Journal of Epidemiology·Laura E Beane FreemanDebra T Silverman
May 26, 2015·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Magdalena GolasikWojciech Piekoszewski
Dec 3, 2016·Journal of Exposure Science & Environmental Epidemiology·William M MendezReeder Sams
Dec 28, 2016·The Science of the Total Environment·Vivien TaylorKevin A Francesconi

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Citations

Dec 31, 2020·Nutrients·Katarzyna Zabłocka-SłowińskaKonrad Pawełczyk
Aug 7, 2021·Environment International·Gwen TindulaMaitreyi Mazumdar
Aug 15, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·May T MaungTeresita Padilla-Benavides

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