PMID: 9638376Jun 25, 1998Paper

A case-control study of true-positive versus false-negative cervical smears in women with cervical intraepithelial neoplasia (CIN) III

Cytopathology : Official Journal of the British Society for Clinical Cytology
J P O'SullivanC A Waddell

Abstract

Cervical smears (n = 150) from five departments showing high-grade dyskaryosis were examined by three cytologists. All the smears came from patients with biopsy-proven CIN III. One hundred had been correctly reported (true positives) but 50 had originally been reported as negative and had been found to be positive only on review (false negatives). There were significant differences between the two sets in the characteristics of the dyskaryotic cell population. The false-negative smears tended to have fewer than 200 dyskaryotic cells. The nuclei of the dyskaryotic cells tended to have fine rather than coarse nuclear chromatin. A smear with fewer than 50 dyskaryotic cells is 26 times more likely to be reported as negative than one with more than 200 dyskaryotic cells. The results suggest that there is a type of severely dyskaryotic smear that is inherently likely to be missed on routine screening.

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Citations

Feb 13, 2001·Diagnostic Cytopathology·G G Birdsong
Jan 10, 2002·Diagnostic Cytopathology·Suzanne M Selvaggi, Barbara J Guidos
Mar 14, 2000·Cytopathology : Official Journal of the British Society for Clinical Cytology·P A Smith
Oct 20, 2006·Journal of Lower Genital Tract Disease·Diane D DaveyJeffrey Waldman
Jul 27, 2000·Journal of Clinical Pathology·A al-NafussiE McGoogan
Mar 15, 2011·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Lizette Elumir-TannerUNKNOWN Southern Alberta Primary Care Research Network (SAPCReN)
Dec 2, 2011·Archives of Pathology & Laboratory Medicine·Karla K EvansJeremy M Wolfe
May 11, 2001·American Journal of Clinical Pathology·S S RaabD M Grzybicki
Nov 14, 2002·American Journal of Clinical Pathology·Diane D DaveyUNKNOWN American Society for Colposcopy and Cervical Pathology
May 25, 2006·Cytopathology : Official Journal of the British Society for Clinical Cytology·D V Coleman, J J R Poznansky
Apr 3, 2007·Cytopathology : Official Journal of the British Society for Clinical Cytology·H G WienerA Herbert
Aug 2, 2006·Cytopathology : Official Journal of the British Society for Clinical Cytology·M Desai, A Herbert
Jan 17, 2012·Cytopathology : Official Journal of the British Society for Clinical Cytology·A CastanonP Sasieni
Mar 20, 2013·Cytopathology : Official Journal of the British Society for Clinical Cytology·A Herbert
Feb 27, 2010·BJOG : an International Journal of Obstetrics and Gynaecology·A HerbertK S Raju
Oct 17, 2003·Clinics in Laboratory Medicine·Michael R Henry
Dec 11, 1999·Manual Therapy·C J Main, P J Watson
May 14, 2016·Cancer Cytopathology·Jennifer M RobertsUNKNOWN Study of the Prevention of Anal Cancer (SPANC) Study Team
Sep 7, 2004·Diagnostic Cytopathology·Ana P Martins SebastiãoLuiz F Bleggi-Torres
Apr 16, 2002·Cytopathology : Official Journal of the British Society for Clinical Cytology·Robin Moseley
Jul 11, 2012·Cytopathology : Official Journal of the British Society for Clinical Cytology·N GuptaJ H F Smith

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