A case-control study on the effects of the apolipoprotein E genotypes in nonalcoholic fatty liver disease.

Molecular Biology Reports
Emma De FeoStefania Boccia

Abstract

Nonalcoholic fatty liver disease (NAFLD) has reached epidemic proportions being the most common cause of chronic liver disease in Western countries. The Apolipoprotein E (ApoE) gene has three major isoforms encoded by the ε2, ε3, and ε4 alleles, with the ε4 allele associated with hypercholesterolemia and the ε2 allele with the opposite effect. The role of apoE genotypes on NAFLD has been previously investigated with conflicting results. Our hospital-based case-control study conducted in Italy aims to explore the effect of the apoE genotypes on NAFLD risk and their effect on the clinical features of NAFLD patients. 310 NAFLD cases and 422 controls were genotyped for apoE. Adjusted odds ratios (ORs) and 95% confidence intervals (CI) from logistic regression were used to explore the relationship between NAFLD and apoE genotypes, as well as their interaction with selected demographic and lifestyle factors. ApoE ε4 allele carriers showed a statistically significant two-fold reduction of NAFLD risk (OR = 0.51, 95% CI: 0.28-0.93) compared with ε3 homozygotes. A statistically significant lower HDL cholesterol level was observed for ApoE ε4 carriers if compared with ε3/ε3 genotype or ApoE ε2 carriers with a nearly linear decreasing tren...Continue Reading

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Citations

Oct 27, 2015·World Journal of Gastroenterology : WJG·Fabio Salvatore MacalusoSalvatore Petta
Aug 7, 2019·PloS One·Eline H van den BergRobin P F Dullaart
Aug 5, 2018·Journal of Lipid Research·Yitian ZhouVolker M Lauschke
Sep 25, 2019·Annals of Hepatology·José C R NascimentoPierluigi Toniutto
Sep 19, 2021·Hepatology Communications·Cameron J FairfieldAthina Spiliopoulou

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