A Case Control Study Reveals that Polyomaviruria Is Significantly Associated with Interstitial Cystitis and Vesical Ulceration

PloS One
Benjamin J WinterDamon P Eisen

Abstract

To investigate whether polyomaviruses contribute to interstitial cystitis pathogenesis. A prospective study was performed with 50 interstitial cystitis cases compared with 50 age-matched, disease-free controls for the frequency of polyomaviruria. Associations between polyomaviruria and disease characteristics were analysed in cases. Polyomavirus in urine and bladder tissue was detected with species (JC virus vs. BK virus) specific, real-time PCR. Case patients were reflective of interstitial cystitis epidemiology with age range from 26-88 years (median 58) and female predominance (41/50 F). There was a significant increase in the frequency of polyomavirus shedding between cases and controls (p<0.02). Polyomavirus shedding, in particular BK viruria, was associated with vesical ulceration, a marker of disease severity, among interstitial cystitis cases after adjustment for age and sex (OR 6.8, 95% CI 1.89-24.4). There was a significant association among cases between the presence of BK viruria and response to intravesical Clorpactin therapy (OR 4.50, 95% CI 1.17-17.4). The presence of polyomaviruria was found to be associated with the ulcerative form of interstitial cystitis. Clorpactin, which has anti-DNA virus activity, was mor...Continue Reading

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Citations

Nov 26, 2015·Drugs·Samuel BelknapDeborah Erickson
Sep 13, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·James A DeCaprio
Oct 13, 2020·Der Urologe. Ausg. A·G MagistroC G Stief
Jun 9, 2021·Aktuelle Urologie·Michael AtzlerGiuseppe Magistro

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Methods Mentioned

BETA
PCR
biopsy
biopsies

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