PMID: 6112301Apr 18, 1981Paper

A case for the antenatal administration of anti-D immunoglobulin to primigravidae

Lancet
L A Tovey, J M Taverner

Abstract

The value and practicability of introducing an antenatal anti-D immunoglobulin programme is a matter of controversy. Those in favour of the programme claim it is the only procedure available which will reduce still further the incidence of Rh sensitisation. Opponents claim it is not cost-effective. An analysis of data collected in the Yorkshire region points to the value of at least giving anti-D antenatally to all Rh-negative primigravidae and, if the baby is found to be Rh-negative, administering anti-D antenatally in the second pregnancy. Mothers developing anti-D antibodies in their first Rh-positive pregnancy are major contributors to the number of infant deaths due to Rh haemolytic disease of the newborn. When anti-D immunoglobulin is given to a mother with no demonstrable antibodies and she develops Rh antibodies in her next Rh-positive pregnancy, the prognosis for the child is good and "failures of protection" of anti-D immunoglobulin rarely result in infant deaths due to Rh antibodies.

References


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Citations

Jun 1, 1991·British Journal of Obstetrics and Gynaecology·M Selinger
Apr 1, 1990·Archives of Disease in Childhood·D J SwinhoeM J Whittle
Jul 6, 1985·British Medical Journal·S J Urbaniak
Oct 4, 1986·British Medical Journal·L A Tovey
Jan 22, 2008·International Journal of Laboratory Hematology·P V SulochanaS Sathyabhama
Sep 1, 1986·British Journal of Obstetrics and Gynaecology·L A Tovey
Feb 1, 1984·The Australian & New Zealand Journal of Obstetrics & Gynaecology·B F JonesR S Nanra
Nov 16, 2004·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Ian Z MacKenzieIrmgard Andresen
Dec 9, 2014·Topics in Spinal Cord Injury Rehabilitation·Melissa T NottStephanie Chilko
Mar 1, 1984·Postgraduate Medicine·J P Lavery

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