A case of a co-secreting TSH and growth hormone pituitary adenoma presenting with a thyroid nodule

Endocrinology, Diabetes & Metabolism Case Reports
Laura Hamilton Adams, Derick Adams

Abstract

Co-secreting TSH and growth hormone pituitary adenomas are rare. We present a case of a 55-year-old woman who presented with symptoms of neck fullness. Ultrasound revealed multiple thyroid nodules and examination revealed several clinical features of acromegaly. She was found to have a co-secreting TSH and growth hormone pituitary macroadenoma. She underwent surgical resection followed by gamma knife radiation, which resulted in complete remission of her TSH and GH-secreting adenoma. TSH-secreting pituitary adenomas are rare and about one-third co-secrete other hormones.Thyroid nodules are common in acromegaly and can be the presenting sign of a growth hormone-secreting pituitary adenoma.In the workup of acromegaly, assessment of other pituitary hormones is essential, even in the absence of symptoms of other pituitary hormone dysfunction.Complete remission of co-secreting GH and TSH pituitary macroadenomas is possible with surgery and radiation alone.

References

Dec 1, 2009·Best Practice & Research. Clinical Endocrinology & Metabolism·Paolo Beck-PeccozIrene Campi
Aug 23, 2012·Arquivos brasileiros de endocrinologia e metabologia·Amelia RogozinskiAlicia Lowenstein
Jan 24, 2015·Endocrinology, Diabetes & Metabolism Case Reports·Philip C JohnstonRobert J Weil
Feb 27, 2016·Journal of Microscopy·Cantwell G Carson, Jonathan S Levine

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Methods Mentioned

BETA
equilibrium dialysis
surgical resection
biopsy

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