A case of ABO*Ael02/O04 genotype with typical phenotype O

The Korean journal of laboratory medicine
Shin-Young JooKyou Sup Han

Abstract

Ael is a rare blood type which has the least amount of A antigen among A subgroups. It can be detected by special tests performed to resolve the discrepancy between red cell and serum typing in routine serological typing. The presence of A antigen on Ael red cell is demonstrable only by adsorption and elution tests. An Ael individual does not secret A substance in the saliva and may have anti-A antibody in the serum which is usually less reactive with the reagent red cells than anti-B antibody. In Korea, Ael02 has been reported more frequently than other Ael alleles. We report a case of Ael02/O04 who presented as typical phenotype O with strong anti-A and anti-B antibodies and no A antigen detected even by adsorption and elution tests. The case has been proved to be Ael02/O04 by direct sequencing analysis. In individuals with history of discrepancies in the results of ABO phenotyping, ABO genotyping is needed for an accurate evaluation of their blood type.

References

Mar 1, 1976·Revue française de transfusion et immuno-hématologie·J P Cartron
May 17, 1990·Nature·F YamamotoS Hakomori
Feb 1, 1995·Glycobiology·F YamamotoS Hakomori
Jun 1, 1997·The Japanese Journal of Human Genetics·S H KangY Okubo
Apr 7, 1999·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·C LegnaniS Coccheri
Aug 1, 2002·Blood·Lung-Chih YuMarie Lin
Jul 19, 2003·Transfusion·Chien-Feng SunMarie Lin
Aug 26, 2003·Legal Medicine·Tatsuyuki OkiuraHiroaki Nishimukai
Jun 7, 2005·Transfusion·Chuan-ging WuMei-ying W Yu
Aug 17, 2005·Transfusion Medicine·D ChoD W Ryang

❮ Previous
Next ❯

Citations

Jan 2, 2015·Annals of Laboratory Medicine·Bo Kyeung JungJi Seon Choi
Feb 8, 2020·Journal of Cellular and Molecular Medicine·Liwei WuJianye Wu
Oct 24, 2012·Journal of Sports Sciences·Anne PankhurstÁine Macnamara

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.