A case of acute and necrotizing cutaneous Mycobacterium marinum infection in a patient treated with infliximab for Crohn's disease

Annales de dermatologie et de vénéréologie
A GuyotB Crickx

Abstract

The increasing use of anti-TNFalpha exposes patients to emerging risks, particularly that of infection. We report a case of severe cutaneous Mycobacterium marinum infection in a patient treated with infliximab and we discuss therapeutic options. A man treated with infliximab for Crohn's disease developed a severe cutaneous infection with M. marinum. Despite withdrawal of infliximab and the introduction of triple antibiotic therapy, the patient's lesions worsened and surgical treatment was required. The worsening experienced by our patient 1 week after the beginning of the treatment is comparable with the immune reconstitution syndrome occasionally observed in tuberculosis in immunocompromised hosts, thus raising the question of the potential value of continuing infliximab treatment. Recommendations are needed concerning the prevention and treatment of M. marinum infections in patients on anti-TNFalpha biotherapies.

References

Jan 17, 2004·Emerging Infectious Diseases·Timothy Lahey
Feb 17, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Carolina Garcia VidalJavier Garau
Jun 29, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Robert S Wallis
Oct 17, 2006·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Nagesh ChopraDavid Widman
Nov 9, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Sandra M ArendJaap T van Dissel
Nov 28, 2007·American Journal of Clinical Dermatology·Efstathios RallisAndreas Katsambas
Mar 7, 2009·Scandinavian Journal of Infectious Diseases·Janine R DankoCatherine F Decker

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Citations

Nov 18, 2009·Annales de dermatologie et de vénéréologie·E Adenis-LamarreM S Doutre
Nov 18, 2009·Annales de dermatologie et de vénéréologie·S Regnier, E Caumes
Oct 19, 2019·The Pediatric Infectious Disease Journal

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