PMID: 22576573May 12, 2012Paper

A case of acute lymphotic leukemia which was difficult to make a diagnosis of CRMO for moving arthralgia and periarticular swelling

Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology
Toshitaka KizawaHiroyuki Tsutsumi

Abstract

A girl, 7 years of age, was reported who had been suffered from migratory arthralgia, bone pain and erythematous rash. She had increased inflammatory markers such as C-reactive protein, erythrocyte sedimentation rate, and mild anemia for more than 6 months. In the beginning, she was suspected of having either juvenile idiopathic arthritis or chronic recurrent multifocal osteomyelitis. However, after about 6 months, there were abrupt increases of LDH in serum titers and blast cells were also revealed by bone marrow examination. Upon these findings, she was diagnosed with acute lymphocytic leukemia. Since bone pain and arthralgia bone pain and arthralgia are both indicative of numerous inflammatory disorders such as infectious myelitis, juvenile chronic arthritis, childhood leukemia and malignancies, and auto-inflammatory bone diseases, especially chronic recurrent multifocal osteomyelitis, it is difficult to accurately diagnose right away. For now, these aforementioned inflammatory responses are the sole key findings for clinical investigations. Other than that, there are not enough reports yet to help diagnose incases similar to this. Therefore, it is difficult to differentiate between the disorders above even after blood tests...Continue Reading

References

Oct 21, 2005·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Keisuke HagiharaKazuyuki Yoshizaki

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