A case of adenoid cystic carcinoma associated with IgG4-related disease

International Journal of Surgery Case Reports
Tsuyoshi ShimoAkira Sasaki

Abstract

Immunoglobulin G4-related disease (IgG4-RD) is an inflammatory condition associated with elevated serum IgG4 levels and tissue infiltration by IgG4-expressing plasma cells. We present a case of adenoid cystic carcinoma (ACC) of the submandibular gland with possible involvement of IgG4-RD. The patient was a 59-year-old man presenting with a swollen right submandibular gland. Laboratory tests revealed IgG4 levels of 176mg/dl (reference range: 4.8-105). An initial open biopsy for histological diagnosis showed chronic sialadenitis. The region was monitored on an outpatient basis, and finally the right submandibular was totally resected because malignant tumor could not be excluded. Histological examination of the submandibular gland showed an ACC with lymphocytic infiltration containing many IgG4-positive plasma cells in the tumor stroma. We have described a case that indicated a possible involvement of ACC with IgG4-RD. This allows us to speculate that longstanding IgG4-RD may progress to malignancy or infiltration of IgG4-positive plasma cells through the signals of tumor stimuli. Further investigations are required to determine the potential pathogenic mechanism underlying this unique tumor. This case underscores that caution is...Continue Reading

References

Jun 15, 1995·International Journal of Radiation Oncology, Biology, Physics·A S GardenL J Peters
Mar 10, 2001·The New England Journal of Medicine·H HamanoK Kiyosawa
Feb 6, 2004·Head & Neck·William M MendenhallDouglas B Villaret
May 29, 2004·Current Opinion in Otolaryngology & Head and Neck Surgery·Patrick J Bradley
Apr 7, 2007·The American Journal of Surgical Pathology·Motohiro KojimaGünter Klöppel
Jan 29, 2008·The American Journal of Surgical Pathology·Satomi KasashimaYasuni Nakanuma
Dec 3, 2010·Current Opinion in Rheumatology·Julia T Geyer, Vikram Deshpande
Jun 30, 2012·The American Journal of Surgical Pathology·Wei TianDouglas R Gnepp

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Citations

May 31, 2016·The Journal of Obstetrics and Gynaecology Research·Rin MizunoToshihiro Higuchi
Mar 20, 2020·Journal of Oral and Maxillofacial Pathology : JOMFP·Sushama Govindrao GurwaleIndranil Dey
Feb 26, 2021·Oncoimmunology·Galateja JordakievaErika Jensen-Jarolim

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Methods Mentioned

BETA
biopsy

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