A case of an anti-Ma2 antibody-positive patient presenting with variable CNS symptoms mimicking multiple system atrophy with a partial response to immunotherapy

Rinshō shinkeigaku = Clinical neurology
Wataru ShiraishiAkifumi Yamamoto

Abstract

A 70-year-old man with a 5-month history of progressive bradykinesia of the bilateral lower extremities was admitted to our hospital. At the age of 64, he underwent proximal gastrectomy for gastric cancer. He also had a history of subacute combined degeneration of the spinal cord since the age of 67, which was successfully treated with vitamin B12 therapy. Four weeks before admission to our hospital, he admitted himself to his former hospital complaining of walking difficulty. Two weeks later, however, his symptoms progressed rapidly; he was immobilized for two weeks and did not respond to the vitamin therapy. On admission to our hospital, he showed moderate paralysis of the lower extremities, cog-wheel rigidity of the four extremities, and dystonic posture of his left hand. He also showed orthostatic hypotension and vesicorectal disorders. Blood examination and cerebrospinal fluid analysis revealed no remarkable abnormalities. Electroencephalography showed frontal dominant, high voltage, sharp waves. His brain and spinal MRI revealed no notable abnormalities. We suspected autoimmune disease and commenced one course of intravenous methylprednisolone therapy, resulting in improvement of the parkinsonism and orthostatic hypotensi...Continue Reading

References

Sep 18, 2001·Annals of Neurology·M R RosenfeldJ Dalmau
Jun 25, 2004·Brain : a Journal of Neurology·Josep DalmauMyrna R Rosenfeld
Jul 20, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·F GrausR Voltz
Dec 20, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·M WaragaiK Tanaka
Dec 8, 2006·Nature·Ed S LeinAllan R Jones
Sep 14, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Nadia StefanovaGregor K Wenning
Jan 29, 2008·Journal of Neurology, Neurosurgery, and Psychiatry·L A HoffmannR Voltz
Nov 3, 2012·BMC Neurology·Peter NovakVera Novak

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Citations

Oct 27, 2015·International Journal of Molecular Sciences·Sonja W Scholz, Jose Bras

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