A case of antiglomerular basement membrane glomerulonephritis complicated by membranous nephropathy

CEN Case Reports
Akira IguchiIchiei Narita

Abstract

The sequential or simultaneous presentation of anti-glomerular basement membrane (anti-GBM) glomerulonephritis with membranous nephropathy (MN) has been infrequently reported. Although the mechanism underlying MN superimposed on anti-GBM glomerulonephritis is unknown, the two entities are believed to be interrelated. We report the case of a 75-year-old woman diagnosed with rapidly progressive glomerulonephritis. Renal biopsy revealed crescentic glomerulonephritis with linear and granular staining of immunofluorescent IgG1 and IgG4 granular staining on the capillary loops. Electron microscopy revealed extensive subepithelial deposits. These findings suggested simultaneous development of anti-GBM glomerulonephritis and MN in this case. Serum phospholipase A2 receptor (PLA2R) antibody was negative. The patient was treated with prednisolone and plasma exchange, resulting in resolution of renal insufficiency and a decrease in urinary protein. The rapid decrease in urinary protein and absence of PLA2R antibody suggest that the mechanism of MN associated with anti-GBM glomerulonephritis differs from that of primary MN.

References

Aug 1, 1989·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J A SavigeP Kincaid-Smith
Jun 13, 1974·The New England Journal of Medicine·J KlassenG A Andres
Sep 1, 1982·American Journal of Clinical Pathology·J C JennetteS S Iskander
May 1, 1984·Clinical Immunology and Immunopathology·E PetterssonA Miettinen
Mar 1, 1981·Clinical Immunology and Immunopathology·Z SharonE J Lewis
Oct 17, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·I S MeiselsA B Kuhlik
Jul 26, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·T SanoY Kobayashi
Sep 27, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·J T KielsteinJ Floege
Aug 6, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Samih H NasrVivette D D'Agati
Jan 30, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Gurmeet R Singh, Wendy E Hoy
Feb 10, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hiroshi OhtaniHirokazu Imai
Jul 3, 2009·The New England Journal of Medicine·Laurence H BeckDavid J Salant
Sep 10, 2011·Journal of the American Society of Nephrology : JASN·Amanda Walton BasfordAgnes B Fogo
Jan 18, 2013·Indian Journal of Nephrology·S ImtiazM Al Khoiter

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.

Related Papers

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
T SanoY Kobayashi
Journal of Nephrology
Simona CurioniGiuseppe D'Amico
American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Erika F RodriguezLynn D Cornell
American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Ashutosh SinghCharney Douglas
© 2022 Meta ULC. All rights reserved