A Case of Atorvastatin-Associated Necrotizing Autoimmune Myopathy, Mimicking Idiopathic Polymyositis

Case Reports in Rheumatology
Ayushi Dixit, Adriana Abrudescu

Abstract

Statin-induced necrotizing autoimmune myopathy (SINAM) is a rare side effect of statin use which manifests as progressive muscle weakness. Because statins are a widely prescribed medication for coronary artery disease, hyperlipidemia, and many other diseases, many patients are at risk of developing SINAM or one of the many other statin-induced myopathies. Due to identification of an antibody specific to this disease, we were able to diagnose SINAM in a patient whose symptoms had progressed to the extent that they were debilitating. Our case describes SINAM in a patient undergoing treatment with a statin for an extended period of time, diagnosis of the disease process, treatment, and resolution of symptoms.

References

Dec 14, 2005·Archives of Internal Medicine·Karen E HansenJames H Stein
Jun 17, 2009·Annals of Internal Medicine·Tisha R Joy, Robert A Hegele
Oct 9, 2009·Muscle & Nerve·Phyllis Grable-EspositoAnthony A Amato
Apr 13, 2013·Clinical Medicine & Research·Rajan KanthRafael Medina Flores
Apr 10, 2015·Journal of General Internal Medicine·Laura NicholsChamindra G Konersman
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May 18, 2016·BMC Ear, Nose, and Throat Disorders·Linh Q NgoElie Gertner

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Citations

May 10, 2019·BMJ Case Reports·Mitchell Pitlick, Floranne Ernste
Jan 19, 2021·Proceedings·Syed A HudaRonald Russo
May 18, 2021·Intractable & Rare Diseases Research·Sonia GuptaJoseph Nahas

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Methods Mentioned

BETA
ELISA
biopsy

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Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

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