A case of biliary adenofibroma with malignant transformation

Pathology, Research and Practice
Elena ThaiEnrico Maria Silini

Abstract

Identifying precursor lesions of cholangiocarcinoma (CC) is relevant for early diagnosis and management. While for distal, perihilar and large duct cholangiocarcinoma, premalignant lesions are being recognized and studied actively, precursors of peripheral CC are still poorly described. Biliary adenofibroma is a rare benign tumor that has been proposed as a possible precursor lesion of peripheral CC. In the present report, we describe a unique case of a peripheral ICC that originated from a benign biliary adenofibroma with areas of atypical papillary proliferation, which is an expression of a multistep process of carcinogenesis.

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Citations

Sep 16, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Paul KaminskyDavid A Gerber
Mar 8, 2017·The American Journal of Surgical Pathology·Thomas ArnasonGregory Y Lauwers
Dec 25, 2019·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Sunyoung LeeKee-Taek Jang
Jul 24, 2021·Pathologica·Samantha SarcognatoMaria Guido
Aug 12, 2021·BMJ Case Reports·Elizabeth BlearsMark Bunker

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