A case of cerebral ganglioneuronal tumor in the parietal lobe of an adult

Brain Tumor Pathology
Hiroshi NishiharaShinya Tanaka

Abstract

Central nervous system (CNS) neuroblastoma/ganglioneuroblastoma is one of the embryonal tumors with neuronal differentiation found in young adults, but it is most common in children, especially in those below the age of 5 years, whereas extraventricular neurocytoma, a rare neuroepithelial tumor with neuronal differentiation, mostly affects young adults. Here we present a rare case of cerebral ganglioneuronal tumor that occurred in a 32-year-old woman. The patient suffered from tonic convulsion, and computed tomography demonstrated a well-demarcated, round tumor 3.3 cm in size with marked calcification in the right parietal lobe. Histological analysis revealed diffuse infiltration of small, round cells with scattered large ganglion-like cells. Immunohistochemically, the tumor cells did not react with any neuronal molecules, except for chromogranin A in ganglion-like large tumor cells, but electron microscopy demonstrated the presence of synapse-like nerve terminal structures without mature postsynaptic density, suggesting the presence of neoplastic tumor components with neuronal differentiation; thus, this tumor was diagnosed as CNS ganglioneuroblastoma with possible low-grade malignancy because the Mib-1 labeling index was less...Continue Reading

References

Dec 1, 1976·Brain : a Journal of Neurology·B C Horten, L J Rubinstein
Sep 1, 1983·Journal of Neurosurgery·M S BergerC B Wilson
Jul 1, 1981·Surgical Neurology·S SakakiK Matsuoka
Nov 2, 2001·The American Journal of Surgical Pathology·D J BratP C Burger

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Citations

Apr 19, 2012·Clinical Neurology and Neurosurgery·Mirjam H SchipperCharles J Vecht
Oct 31, 2015·Seminars in Cell & Developmental Biology·Cristina Tocchini, Rafal Ciosk

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