A case of chronic eosinophilic pneumonia in a patient treated with dupilumab

Therapeutics and Clinical Risk Management
Francesco MenzellaNicola Facciolongo

Abstract

The increasing knowledge on inflammatory pathways has driven the development of targeted biological therapies for severe refractory asthma. Among the recently developed biologics, the fully human monoclonal antibody dupilumab is an interesting therapeutic option, given its ability to inhibit the biological effects of both IL-4 and IL-13. We describe the case of a male, Caucasian, 56-year-old patient with allergic and eosinophilic severe asthma. Given the poor asthma control, he started treatment with add-on dupilumab, and after the tenth injection, he presented with a fever and bilateral pulmonary thickening. A significant increase in blood eosinophilia was also reported. The patient underwent a fiberoptic bronchoscopy with bronchoalveolar lavage (BAL) and transbronchial lung biopsy (TBLB/TBB). BAL revealed eosinophils alveolitis (60%) while TBB showed findings compatible with chronic eosinophilic pneumonia (CEP). After prolonged treatment with oral corticosteroids, the clinical picture improved with resolution of CEP. Since the beginning of dupilumab treatment, simultaneously to a great improvement in asthma control, the patient showed a progressive increase in blood eosinophils count and subsequent onset of clinical-radiologi...Continue Reading

Citations

Sep 11, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Hani Harb, Talal A Chatila
Oct 9, 2019·Expert Opinion on Drug Safety·Patrick Mitchell, Richard Leigh
Jan 10, 2020·Expert Opinion on Biological Therapy·Angela Moran, Ian D Pavord
Nov 7, 2019·Current Opinion in Allergy and Clinical Immunology·Diego BagnascoGiovanni Passalacqua

Aug 29, 2020·Laryngo- rhino- otologie·L KlimekC Bachert
Mar 19, 2020·Therapeutics and Clinical Risk Management·G Daniel Brooks
Jun 23, 2020·Case Reports in Gastrointestinal Medicine·Masaya IwamuroHiroyuki Okada
Feb 6, 2020·Internal Medicine·Kohsuke IsomotoTakashi Ogura
Oct 7, 2020·Pediatric Pulmonology·Christopher Fowler, Wynton Hoover
Mar 7, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Katrien EgerElisabeth H Bel

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Methods Mentioned

BETA
X
ray
bronchoalveolar
biopsy
biopsies

Software Mentioned

VENTURE

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