PMID: 22576399May 12, 2012Paper

A case of chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) in East Asia

Internal Medicine
Rie TohgeShiro Matsubara

Abstract

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) syndrome is a clinically and radiologically distinct pontine-predominant perivascular neuroinflammation showing T lymphocyte infiltration. It is assumed to have an autoimmune or other inflammatory mediated pathogenesis. We report the first known case of CLIPPERS in East Asia, characterized by multiple punctate enhancement of the brainstem extending to the bilateral posterior limb of the internal capsule and caudal to the spinal cord conus. The patient had elevated IgE levels and a history of allergies, suggesting that lesions may arise from neuroinflammation in response to T lymphocyte infiltration into perivascular spaces.

Citations

Feb 4, 2014·Journal of Neuropathology and Experimental Neurology·Bette Kay Kleinschmidt-DeMasters, Matthew West
Aug 9, 2015·World Neurosurgery·Majid EsmaeilzadehJoachim K Krauss
Jan 24, 2018·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·S A SivertsevaA N Boyko
Jul 21, 2017·Current Neurology and Neuroscience Reports·Nicholas L Zalewski, W Oliver Tobin
Mar 16, 2019·Child Neurology Open·Tarishi NemaniShridhar Epari
Jul 15, 2021·Radiology Case Reports·Maria Andrea Parra CorralSajeev R Ezhapilli Chennan

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