A case of cicatricial alopecia associated with erlotinib.

Annals of Dermatology
Bo Hee YangGwang Seong Choi

Abstract

Erlotinib is a small-molecule tyrosine kinase inhibitor (TKI) of the epidermal growth factor receptor (EGFR). Erlotinib has been used primarily to treat non-small cell lung cancer. In addition to its role in tumor cells, EGFR is also an important regulator of growth and differentiation in the skin and hair. Therefore, EGFR-TKIs have been associated with a number of cutaneous side effects including follicular acneiform eruptions, cutaneous xerosis, chronic paronychia, desquamation, seborrheic dermatitis, and hair texture changes. Herein, we report a rare case of a 61-year-old woman who was treated with erlotinib and experienced cicatricial alopecia.

References

Jul 5, 2005·The Lancet Oncology·Caroline RobertThierry Le Chevalier
Jul 18, 2006·Journal of the American Academy of Dermatology·Julia E GravesMichael P Heffernan
Oct 3, 2006·Journal of the American Academy of Dermatology·Anna Liza C AgeroAllan C Halpern
Dec 20, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Daniel B CostaSusan T Schumer
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May 12, 2010·Clinical and Experimental Dermatology·R Hoekzema, P Drillenburg

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Citations

Sep 5, 2015·Current Treatment Options in Oncology·Silvina B PuglieseBernice Y Kwong
Jan 17, 2015·Journal of the American Academy of Dermatology·James B MacdonaldAleksandar Sekulic
Jan 31, 2017·The American Journal of Dermatopathology·Jonathan J LeeMai P Hoang
Aug 28, 2012·Dermatology : International Journal for Clinical and Investigative Dermatology·Nagomi TodaToshihiro Tanaka
Jan 8, 2020·International Journal of Women's Dermatology·Michelle N FerreiraJonathan S Leventhal
Mar 4, 2020·Experimental Dermatology·Jonas A AdalsteinssonJonathan Ungar

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Methods Mentioned

BETA
biopsy

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