A case of clinically and neuropathologically atypical corticobasal degeneration with widespread iron deposition

Acta Neuropathologica
Y MizunoH Shibayama

Abstract

A 65-year-old woman was admitted to our hospital for forgetfulness, depression and eccentric behavior that had been first noticed 2 years prior to admission. She showed memory impairment, perseveration and repeated violent actions, but no limb-kinetic apraxia. She died 12 years after the onset of symptoms. At autopsy, the unfixed brain weighed 820 g. Atrophy was circumscribed in the frontal lobe on both sides. The globus pallidus and the caudate nucleus were markedly atrophic and gold yellow in color, and the substantia nigra was strikingly pale. The cortical area showed neuronal loss and status spongiosus of the second and third cortical layers with ballooned neurons. Marked neuronal loss was observed in the dorsomedial nucleus of the thalamus, Meynert basal nucleus and substantia nigra. With Holzer stain, fibrillary gliosis was found to be severe in the frontal lobe, globus pallidus, subthalamic nucleus, hippocampus, dorsomedial nucleus of thalamus, substantia nigra, pontine tegmentum and inferior olivary nucleus. With Bielschowsky-Hirano stain, neurofibrillary tangles were observed in the cortex, hippocampus, substantia nigra, dentate nucleus, subthalamic nucleus, pontine nucleus, the inferior olivary nucleus, dorsomedial nu...Continue Reading

Citations

Dec 18, 2014·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Daizo KondoEizo Iseki
Jul 23, 2013·Parkinsonism & Related Disorders·Robert FeketeWilliam Ondo
Aug 10, 2017·Reviews in the Neurosciences·Sotirios Apostolakis, Anna-Maria Kypraiou
Jul 4, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Daniela Berg, Helmine Hochstrasser
Dec 21, 2006·Topics in Magnetic Resonance Imaging : TMRI·Daniela Berg, Moussa B H Youdim

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