A Case of Corneal Neovascularization Misdiagnosed as Total Limbal Stem Cell Deficiency

Cornea
Qi-hua LeSophie X Deng

Abstract

To report a case of corneal neovascularization misdiagnosed as total limbal stem cell deficiency (LSCD). This is a case report of a 61-year-old woman who has a history of bilateral idiopathic scleritis, keratitis, and uveitis for more than 20 years. She was diagnosed with total LSCD in her left eye based on clinical presentation alone and was confirmed as a candidate for limbal transplantation at several major tertiary eye care centers in the United States. After referral to the Stein Eye Institute, in vivo confocal microscopy (IVCM) and anterior segment optical coherence tomography (AS-OCT) were performed to clarify the diagnosis. Slit-lamp examination of the left eye revealed 360-degree severe thinning at the limbus and peripheral corneal pannus and neovascularization that spared the central cornea, a smooth epithelium without fluorescein staining at the central cornea, an uneven surface, and pooling of fluorescein at the peripheral cornea accompanied by minimal fluorescein staining of the sectoral peripheral epithelium. IVCM showed that epithelial cells in the central cornea exhibited a corneal phenotype and that the morphology of the epithelium in all limbal regions except the nasal limbus was normal. Epithelial cellular de...Continue Reading

References

Oct 5, 2010·Ophthalmology·Jose Santiago López-GarcíaJuan Murube del Castillo
Feb 14, 2012·The British Journal of Ophthalmology·Ammar MiriHarminder S Dua
Nov 7, 2012·American Journal of Ophthalmology·Mario NubileLeonardo Mastropasqua
Jul 24, 2014·Investigative Ophthalmology & Visual Science·Yujing YangJianjiang Xu
Jul 8, 2015·American Journal of Ophthalmology·Eric H ChanSophie X Deng
Nov 9, 2017·The Ocular Surface·Qihua LeSophie X Deng

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Citations

Jan 8, 2019·Cornea·Sophie X DengUNKNOWN and The International Limbal Stem Cell Deficiency Working Group
Apr 24, 2020·JAMA Ophthalmology·Qihua LeSophie X Deng
May 6, 2020·Vestnik oftalmologii·A N KulikovS V Churashov
Feb 12, 2021·Experimental Eye Research·Clémence BonnetSophie X Deng
Mar 7, 2021·Progress in Retinal and Eye Research·Clémence BonnetSophie X Deng
Sep 14, 2021·Stem Cells Translational Medicine·Ingrid W CarasAbla A Creasey

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