A case of Crohn's disease involving the gallbladder

World Journal of Gastroenterology : WJG
Akira AndohYoshihide Fujiyama

Abstract

Crohn's disease is well known to affect any part of the gastrointestinal tract including the oral cavity and anus. Various extraintestinal complications have been reported in Crohn's disease, but extraintestinal involvement characterized by granulomatous lesions is uncommon. Here, we have reported a case about the involvement of the gallbladder in Crohn's disease. A 33-year-old woman was diagnosed having panperitonitis due to intestinal perforation and cholecystitis. The patient was moved to the surgical service for an emergency operation. On the resected specimen, there was a broad longitudinal ulcer at the mesenteric side. The mucosa of the gallbladder was nodular and granular, and the wall was thickened. The surface epithelium of the gallbladder was partially eroded and pyloric gland metaplasia was observed focally. Rokitansky-Aschoff sinuses were also present. From the lamina propria to the subserosal layer, there were several well-formed epithelioid cell granulomas, which were the non-caseating sarcoidal type different from the foreign-body and xanthomatous granulomas. Periodic-acid Schiff and acid fast stains revealed no organism within the granulomas. Lymphoid aggregates were present throughout the gallbladder wall. Sect...Continue Reading

References

May 1, 1984·Journal of Clinical Pathology·J McClureP S Schofield
Mar 1, 1993·Journal of Clinical Gastroenterology·A B PostR J Tuthill
May 11, 1999·The American Journal of Gastroenterology·A LapidusO Muhrbeck

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Citations

Jul 29, 2006·World Journal of Gastroenterology : WJG·Akira Andoh, Yoshihide Fujiyama
Sep 24, 2021·BMJ Case Reports·Callam ScottJonathan C MacDonald

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