A case of Crohn's disease that developed anti-infliximab and anti-adalimumab antibodies

Clinical Journal of Gastroenterology
Kenichiro TakahashiAkira Andoh

Abstract

There are few reports about the rapid appearance of anti-adalimumab antibodies in patients with Crohn's disease positive for anti-infliximab antibodies. We report the case of a 29-year-old female patient with a diagnosis of Crohn's disease who revealed a loss of response to infliximab due to high levels of antibodies to infliximab, and did not respond to the subsequent therapy by adalimumab, with a rapid appearance of antibodies to adalimumab. As one of the possible mechanisms of non-response to adalimumab, immunologic reactivity of infliximab to adalimumab was suspected, since the patient's IgG that was obtained just before the induction of adalimumab reacted with infliximab and adalimumab. We should pay attention to the easy appearance of anti-adalimumab antibodies in association with reactivity of anti-infliximab antibodies to adalimumab in patients with high levels of anti-infliximab antibodies.

References

Jun 30, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Stephen B HanauerPaul Rutgeerts
May 2, 2007·Annals of Internal Medicine·William J SandbornPaul F Pollack
Aug 12, 2008·Alimentary Pharmacology & Therapeutics·R L WestC J van der Woude
Mar 24, 2011·The American Journal of Gastroenterology·Henit Yanai, Stephen B Hanauer
Apr 14, 2011·JAMA : the Journal of the American Medical Association·Geertje M BarteldsGerrit Jan Wolbink
Jan 21, 2012·Journal of Crohn's & Colitis·Casper SteenholdtMark Andrew Ainsworth
Jun 11, 2014·The American Journal of Gastroenterology·Xavier RoblinS Paul

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Citations

Apr 5, 2016·Journal of Gastroenterology and Hepatology·Yukihiro MoritaAkira Andoh

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