A case of dextrocardia following maternal exposure to generic Fingolimod during the first trimester of pregnancy

Multiple Sclerosis and Related Disorders
Samira Navardi, Mohammad Ali Sahraian

Abstract

Fingolimod, taken orally once per day, is approved for the treatment of relapsing-remitting multiple sclerosis (MS). It should be stopped at least two months before conception as it is not considered safe during pregnancy or when breast feeding. In vitro and animal studies have found a possibly increased risk of congenital abnormalities following exposure to Fingolimod. Here, we report a 34-year-old female, with a 10-year history of MS who had unexpected pregnancy with exposure to generic Fingolimod during the first 7 weeks. The infant was born with dextrocardia, but without any further structural cardiac or other abnormalities.

Citations

Jun 17, 2020·Multiple Sclerosis : Clinical and Laboratory Research·Emmanuelle PauliatUrsula Winterfeld

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