PMID: 7542975Apr 1, 1995Paper

A case of diabetic amyotrophy associated with 3243 mitochondrial tRNA(leu; UUR) mutation and successful therapy with coenzyme Q10

Endocrine Journal
Y SuzukiT Asahina

Abstract

We report the case of 71-year-old male who was once diagnosed as having diabetic amyotrophy, because of pronounced wasting in proximal muscles, massive weight loss, and development of paresthesia in his legs. Afterwards, ragged red fibers and mitochondrial tRNA mutation at position 3243 were documented in muscle biopsy. He had diabetes mellitus associated with 3243 mitochondrial DNA mutation, suggesting that clinically, diabetic amyotrophy may be overlapped with mitochondria-related disease entities in some parts. Coenzyme Q10 administration was effective in relieving the symptoms in his legs, fatigue, and residual urine in his bladder. These were confirmed with the improvement in neurological parameters. In conclusion, this case gives important help in understanding myopathy in diabetes. It would be important to check on the 3243 mitochondrial tRNA mutation in patients with diabetic amyotrophy and/or diabetic neuropathic symptoms.

Citations

May 1, 1995·Diabetes Research and Clinical Practice·Y SuzukiK Matsuoka
Jul 1, 1995·Diabetes Research and Clinical Practice·Y SuzukiK Matsuoka
Oct 22, 2003·Molecular Genetics and Metabolism·Gregory M Enns
Jan 2, 2007·Pancreas·João Eduardo SallesRegina S Moisés
Nov 1, 2012·Nutrition Reviews·Florence M Sohet, Nathalie M Delzenne
Feb 26, 2008·Diabetic Medicine : a Journal of the British Diabetic Association·R MurphyA T Hattersley
Jan 9, 2013·Arquivos brasileiros de endocrinologia e metabologia·Patricia B MoryRegina S Moisés
Jun 1, 1997·Annals of Medicine·A Suomalainen
Jul 7, 1999·Journal of Pediatric Endocrinology & Metabolism : JPEM·M E DamoreS DiMauro

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