A case of disseminated microscopic demyelination with multifocal dystrophic calcification.

Neuropathology : Official Journal of the Japanese Society of Neuropathology
Maryam AbdollahiDavid G Munoz

Abstract

We present a 47-year-old woman with a 10-year disease course consisting of episodic confusion, aphasia, psychosis, depression, migrainous headaches and seizures. There was mild elevation of protein levels in the cerebrospinal fluid, progressive cerebral atrophy, and numerous small T1 hypointensities appearing as central "holes" in the corpus callosum on magnetic resonance imaging. She eventually expired due to status epilepticus and subsequent significant respiratory complications. In the central nervous system, there was generalized brain atrophy, and patchy labeling of blood vessels by antibodies to complement component 4d (C4d) and membrane attack complex. Innumerable small patches with loss of cell bodies (neurons and glial cells in gray matter and glial cells in white matter) and demyelination were scattered throughout the brain and spinal cord. There was no cavitation and the passing axons were mostly preserved. Large solid calcified foci were present predominantly in the pons along with disseminated focal calcification involving neuron cell bodies, neurites, and capillaries. Patchy labeling of glial cells and linear structures suggestive of myelin sheaths with C4d antibodies was observed while immunostains for SV40, tau,...Continue Reading

References

Mar 1, 1979·Neurology·J O SusacJ B Selhorst
Oct 31, 2006·Journal of Clinical Pathology·S Love
Mar 3, 2007·Journal of the Neurological Sciences·John O SusacMartin Lubow
Sep 22, 2010·Journal of the Neurological Sciences·Robert RennebohmRobert B Daroff
Nov 19, 2011·American Journal of Clinical Pathology·Cynthia M MagroJohn O Susac
Feb 9, 2012·Annual Review of Pathology·Bogdan F Gh Popescu, Claudia F Lucchinetti
May 30, 2012·Journal of the Neurological Sciences·I KleffnerE B Ringelstein
Aug 30, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Todd A HardyMichael E Buckland
Feb 19, 2015·Journal of Stroke·Jay Chol Choi
Jan 20, 2017·Journal of Neurology, Neurosurgery, and Psychiatry·Ilka KleffnerUNKNOWN European Susac Consortium (EuSaC)
Sep 2, 2017·Journal of Neurology, Neurosurgery, and Psychiatry·Jonathan I SpencerGabriele C DeLuca
May 18, 2019·Journal of Neuropathology and Experimental Neurology·Dimitri P AgamanolisRobert M Rennebohm

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