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A Case of Diverticular Perforation in a Young Patient with Rheumatoid Arthritis on Methotrexate

Case Reports in Medicine

Apr 29, 2015

Ian ChangHeather S Laird-Fick

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Abstract

Background. Disease-modifying antirheumatic drugs (DMARDs), such as methotrexate (MTX), are associated with gastrointestinal toxicity. MTX inhibits dihydrofolate reductase, but it is unclear if polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene predict toxicity. Case....read more

Mentioned in this Paper

Antirheumatic Agents
Gene Polymorphism
Methylenetetrahydrofolate reductase (NADPH)
Study
Naproxen
Drug-Induced Liver Injury
Glucocorticoids
Genetic Polymorphism
Glucocorticoids, Systemic
Gastrointestinal Diseases
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A Case of Diverticular Perforation in a Young Patient with Rheumatoid Arthritis on Methotrexate

Case Reports in Medicine

Apr 29, 2015

Ian ChangHeather S Laird-Fick

PMID: 26064129

DOI: 10.1155/2015/617268

Abstract

Background. Disease-modifying antirheumatic drugs (DMARDs), such as methotrexate (MTX), are associated with gastrointestinal toxicity. MTX inhibits dihydrofolate reductase, but it is unclear if polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene predict toxicity. Case....read more

Mentioned in this Paper

Antirheumatic Agents
Gene Polymorphism
Methylenetetrahydrofolate reductase (NADPH)
Study
Naproxen

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