PMID: 25750317Mar 10, 2015Paper

A case of endobronchial NUT midline carcinoma with intraluminal growth.

Anticancer Research
Sho WatanabeNobuyuki Kobayashi

Abstract

NUT midline carcinoma (NMC) is a rare, lethal form of differentiated squamous cell carcinoma characterized by chromosomal rearrangement of the NUT gene. Its highly aggressive nature commonly leads to unresectable and metastatic lesions. We report on a case of endobronchial NMC in a middle-aged man who was treated by bronchoscopic electrocautery followed by Ewing sarcoma-based chemotherapy with concurrent chemoradiotherapy. The patient's disease continued to be stable 31 months after diagnosis. NMC is a challenging disease entity, which is difficult to diagnose and treat, and has a dismal overall survival. Most cases of NMC are widely metastatic or unresectable when diagnosed. This is the first reported case that involves intraluminal tumour growth of NMC and demonstrates the effectiveness of early intensive local therapy aided by bronchoscopic techniques.

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Daniel E BauerChristopher French
Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Naomi FujiokaRobert A Kratzke
Archives of Pathology & Laboratory Medicine
Brian N DavisYolanda Musgrave Brill
Pediatric Blood & Cancer
Ossama M MaherNidale Tarek
© 2022 Meta ULC. All rights reserved