PMID: 9542615May 23, 1998Paper

A case of episodic angioedema associated with blood eosinophilia: upregulated C5a receptor expression on eosinophils

Allergy
K NakashimaM Abe

Abstract

A 47-year-old woman was admitted to hospital complaining of swelling and pain of the extremities, accompanied by high fever and generalized erythema. Laboratory examination showed marked blood eosinophilia with elevation of IgM, IgE, and C-reactive protein. All autoantibodies examined were negative. The heart and lungs showed no untoward findings. Biopsies of the skin and muscle revealed cellular infiltration of eosinophils around small blood vessels. Quantitation of C5a receptor (C5aR) expression by flow cytometry using anti-C5aR antibody showed upregulated expression of C5aR on blood eosinophils but downregulated expression on neutrophils. The abnormal C5aR expression on eosinophils and neutrophils became normal after spontaneous resolution of symptoms and blood eosinophilia. The possibility that C5aR expression on granulocytes is related to the pathogenesis of this syndrome may be considered.

References

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Citations

Oct 13, 2005·Clinical Rheumatology·Masayuki MatsudaShu-ichi Ikeda
Aug 16, 2008·Clinical Rheumatology·Ingrid StocknerChristian J Wiedermann
Jul 31, 2001·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·A CianferoniA Vierucci
Jan 3, 2009·La Revue de médecine interne·C AgardM Hamidou
Nov 7, 2006·Immunology and Allergy Clinics of North America·Aleena BanerjiJaved Sheikh
Feb 7, 2009·Critical Care : the Official Journal of the Critical Care Forum·Michael A FlierlKyros Ipaktchi
Jun 20, 2020·International Journal of Dermatology·Roger HaberAntoine Salloum
Dec 15, 2006·International Journal of Immunopathology and Pharmacology·E NovembreA Vierucci

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