A case of essential mixed cryoglobulinemia and associated acquired von-Willebrand disease treated with rituximab

Journal of Thrombosis and Thrombolysis
Semir PasaEkrem Muftuoglu

Abstract

Current treatment options of essential mixed cryoglobulinemia (EMC); include immunosuppressive approaches, such as corticosteroids, cyclophosphamide, plasma exchange, other cytotoxic drugs in moderate to severe manifestations. Some controlled studies have been carried out to assess the efficacy of anti-CD20 monoclonal antibody, rituximab in patients with hepatitis C (HCV) related cryoglobulinemia (CG) and in patients with autoimmune disorders. Recent trials and some case reports demonstrate a beneficial role for rituximab in HCV related mixed CG. Although, the published evidence for treatment of EMC with rituximab is restricted to case reports, which have shown positive results. Several diseases include lymphoproliferative and myeloproliferative disorders, solid tumors, immunological disorders, cardiovascular disorders and some drugs associated with acquired von Willebrand disease (avWD). CG, which is a kind of immune complex disease, may be related with development of autoantibodies to various autoantigens. In this present case report, we showed the efficacy of rituximab in a 21-year-old female patient, suffered from neuropathy and arthralgia related with EMC, and developed avWD, presented with mucosal bleeding associated with...Continue Reading

References

Jan 20, 2005·Rheumatology·H Nehme-SchusterT Martin
Nov 30, 2006·American Journal of Hematology·Massimo Franchini, Giuseppe Lippi
Jul 13, 2007·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Thiago Carlos Gonçalves RegoAndréia Patrícia Gomes
Aug 19, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Marcella VisentiniMilvia Casato
Dec 6, 2007·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Salvatore De VitaMartina Fabris
Nov 21, 2007·Hematology·Charles S Eby

❮ Previous
Next ❯

Citations

May 16, 2009·Current Opinion in Hematology·Bryan R Whelan, David A Isenberg
Jun 29, 2011·Rinshō shinkeigaku = Clinical neurology·Maki UedaJun-ichi Kira
Aug 16, 2021·Hematology/oncology Clinics of North America·Arielle L Langer, Nathan T Connell

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Haemophilia : the Official Journal of the World Federation of Hemophilia
F BiondoM Mazzucconi
Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Marco MassariGiacomo Magnani
Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
S De VitaM Fabris
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Dario RoccatelloLuigi M Sena
© 2021 Meta ULC. All rights reserved