A case of falciparum malaria successfully treated with intravenous artesunate

Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases
C YasuokaShigeyuki Kano

Abstract

The case was a 47-year-old Nigerian male who was thought to have contracted malaria in Nigeria and then manifested fever with chill, arthralgia and diarrhea in Japan. The blood test at International Medical Center of Japan revealed thrombocytopenia and anemia. Ring forms of 0.03% of his RBCs and ICT Malaria P.f/P.v test was also positive for Plasmodium falciparum. We prescribed mefloquine to him, but the number of the paresites in his peripheral blood did not decrease, and, in fact, they came to increase (maximum 6.66%) 20 hours after the drug treatment. As clinical condition of malaria were liable to change seriously, intravenous Artesunate (a qinghaosu derivative) was decided to be given additionally to the patient. Consequently the parasites disappeared in 20 hours from his blood but a low grade fever still continued possibly because of cholecystitis. At the same time of Artesunate treatment, hemoglobinuria started and anemia worsened partly because of his G-6-PD deficiency. All pending problems were improved by the time he left Japan and those parasites were finally found to be susceptible for mefloquine by the in vitro susceptibility test. This is the first reported case of falciparum malaria successfully treated with intr...Continue Reading

Citations

Jun 11, 2010·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Shigeyuki Kano
Jan 28, 2004·Acta Tropica·Shigeyuki Kano, Mikio Kimura
Jul 8, 2011·The American Journal of Tropical Medicine and Hygiene·Justin M CurleyRobert A Gasser

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Related Papers

Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases
Sadako YoshizawaKeizo Yamaguchi
Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases
Ichiro ItodaShigeyuki Kano
Kansenshōgaku zasshi. The Journal of the Japanese Association for Infectious Diseases
Yasutaka MizunoShigeyuki Kano
© 2021 Meta ULC. All rights reserved