A Case of Fibrillary Glomerulonephritis with Fibril Deposition in the Arteriolar Wall and a Family History of Renal Disease

Case Reports in Nephrology and Dialysis
Kentaro WatanabeShinichi Nishi

Abstract

Herein, we report a case of fibrillary glomerulonephritis (FGN). FGN usually shows non-amyloidal fibrils in the mesangium and glomerular capillary walls on electron microscopy. Inherited cases of FGN have been reported in only 3 families, and the suspected genetic form was autosomal dominant. In the present case, the deposition of microfibrils in the arteriolar wall as well as the glomerulus is unique. Our patient's father died of nephrotic syndrome, and his elder brother had a biopsy-proven glomerulopathy. The histological findings of the brothers are similar to mesangial proliferative glomerulonephritis and resemble each other. Therefore, our case is presumed to be familial FGN. Additionally, herein, we review the literature and reconsider the histological and clinical characters of FGN.

References

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Jun 13, 2015·Nephrology·Tracey YingAndrew Mallett

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Citations

Nov 7, 2019·Clinical Journal of the American Society of Nephrology : CJASN·Nicole K AndeenKelly D Smith
Mar 27, 2021·Current Opinion in Nephrology and Hypertension·Nicole K Andeen, Rupali S Avasare
Jan 12, 2021·KI Reports·Anushya JeyabalanGerald B Appel
Aug 11, 2020·KI Reports·Nicole K AndeenIbrahim Batal

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Methods Mentioned

BETA
biopsy
electron microscopy
light microscopy

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