PMID: 109474Apr 1, 1979

A case of gamma 3 heavy chain disease with vacuolated plasma cells: a clinical, immunological, and ultrastructural study

Journal of Clinical Pathology
W W FeremansC Bieva


A patient with lambda Bence-Jones proteinuria, Waldenström's macroglobulinaemia, and Franklin's disease (gamma HCD), but without clinical evidence of a lymphoproliferative disorder, is presented. The serum contained two distinct immunoglobulin abnormalities: a monoclonal immunoglobulin M (IgM) of lambda type, and a protein fragment which was immunologically related to immunoglobulin G (IgG) and devoid of light chain activity. This gamma HCD protein belongs to the gamma 3 subclass with a molecular weight of approximately 60,000 daltons. The urine contained a Bence-Jones lambda protein as well as the gamma HCD fragment. The two paraproteins were probably secreted by two different malignant clones. Ultrastructural study revealed pathological vacuolated plasma cells of a sort that has hitherto been principally described in association with micron HCD. The mechanism of the intracellular storage of pathological immunoglobulins is discussed in the light of the ultrastructural study.


Jan 1, 1975·Archives of Internal Medicine·D Zucker-Franklin
Jan 1, 1975·Archives of Internal Medicine·E C Franklin
Apr 10, 1971·British Medical Journal·J R Hobbs
Jan 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·B G Johansson
Jan 1, 1973·The American Journal of Medicine·A S JosephsonL Biro
Jul 1, 1973·The American Journal of Medicine·K J BlochE Haber
Sep 1, 1965·Immunochemistry·G ManciniJ F Heremans
Dec 1, 1970·American Journal of Clinical Pathology·E R Fisher, Z A Zawadzki
May 7, 1970·The New England Journal of Medicine·H S BallardC H Illes
Dec 1, 1965·American Journal of Clinical Pathology·J E MaldonadoA L Brown
Feb 1, 1961·The Journal of Biophysical and Biochemical Cytology·J H LUFT
Sep 1, 1964·The American Journal of Medicine·E C FranklinM MELTZER
Sep 1, 1964·The American Journal of Medicine·E F Osserman, K TAKATSUKI


Jul 16, 2003·Medicine·D L Wahner-RoedlerRobert A Kyle
Jan 1, 1981·CRC Critical Reviews in Biochemistry·C Brack
Jul 1, 1987·European Journal of Haematology·T Kanoh, H Nakasato

Related Concepts

Bence Jones Protein SUT
Mu-Chain Disease
Gamma-2b-Immunoglobulin Heavy Chain
Immunoglobulin Heavy Chain Subgroup VH-III
Familial Waldenstrom's Macroglobulinaemia
Plasma Cells

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