A case of hypertrophic herpes simplex virus affecting the eyelid and cornea masquerading as IgG4-related disease

American Journal of Ophthalmology Case Reports
Prachi DuaAllison E Rizzuti

Abstract

To report a case of hypertrophic herpes simplex virus (HSV) of the eyelid and cornea masquerading as IgG4-related disease. A 37-year old African American female with a past medical history of human immunodeficiency virus (HIV) on highly active antiretroviral therapy (HAART) and a recent history of treated genital herpes, presented with an ulcerative lesion of the left upper and lower eyelids, and severe ocular inflammation with symblepharon. Initially, eyelid biopsy revealed findings consistent with IgG4-related disease, and the patient was treated with high dose oral prednisone. After one week of therapy, there was no improvement in the patient's symptoms, and she subsequently developed a corneal epithelial defect which progressed to chronic ulceration. Repeat biopsy and corneal cultures revealed herpes simplex virus type 2. The patient was treated with high dose acyclovir, and the lid lesion improved. The conjunctival inflammation and corneal epithelial defect resolved but symblepharon restricting her eye movement remained. She also developed corneal vascularization and opacification causing severe vision loss. Chronic hypertrophic herpes simplex virus infection is a rare condition reported in patients with HIV. While there h...Continue Reading

Citations

Jan 18, 2019·Experimental and Therapeutic Medicine·Na Wu, Feng Yuan Sun
Jan 14, 2020·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Bruna Morassi SassoRafael Fantelli Stelini
Jul 8, 2021·Ocular Immunology and Inflammation·Naveen RadhakrishnanRathinam S R

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BETA
biopsy
biopsies

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