A case of hypomania during nicotine cessation treatment with bupropion

Addiction Science & Clinical Practice
Karine Giasson-Gariépy, Didier Jutras-Aswad

Abstract

Antidepressants can increase the spontaneous risk of hypomania or mania when used for treatment in affective disorders. When prescribed as an antidepressant, bupropion is generally considered to have a lower relative risk of inducing mood shifts. We describe the case of a 67-year-old man known for dysthymic disorder in remission on quetiapine and venlafaxine who experienced a first lifetime episode of hypomania with the introduction of bupropion SR for smoking cessation. To the best of our knowledge, this is the first case report of bupropion-induced mood shift when used specifically for nicotine cessation in a nonbipolar patient. This case highlights the need for clinicians who prescribe bupropion for smoking cessation to perform regular and systematic mood follow-ups during treatment. These follow-ups could even be more important when bupropion is selected to quit smoking in a patient already taking an antidepressant.

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Citations

Jan 28, 2016·Journal of Pharmacology & Pharmacotherapeutics·Jitendra Kumar Verma, Satyakam Mohapatra
Aug 18, 2016·Journal of Medical Case Reports·Anthony A OlashorePhilip R Opondo
Nov 3, 2016·The Mental Health Clinician·Stephanie Dwyer, Robin Hieber

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