A case of immune checkpoint inhibitor-related colitis with a distinctive endoscopic finding of colonic pseudolipomatosis.

Clinical Journal of Gastroenterology
Tatsushi NaitoYasunari Nakamoto

Abstract

A man in his 70s received anticancer chemotherapy with the anti-programmed cell death protein-ligand 1 antibody atezolizumab for non-small cell lung cancer. Ten days later, he developed diarrhea and skin rash, which were suspected to be due to immune-related adverse events, and was treated with prednisolone for 2 weeks. Five weeks after atezolizumab administration, he was admitted to our hospital for Common Terminology Criteria for Adverse Events Grade 3 diarrhea and hematochezia. Sigmoidoscopy revealed a dark red color in the mucosa of the transverse colon and multiple whitish mucosal plaques extending from the transverse colon to the rectum. Biopsy specimens revealed empty vacuoles in the lamina propria with infiltration of numerous inflammatory cells, including CD8+ T cells. Based on the findings of sigmoidoscopy and histology, the diagnosis was immune checkpoint inhibitor-related colitis with colonic pseudolipomatosis. The endoscopic findings and symptoms were markedly improved by prednisolone administration. We herein report the first case of immune checkpoint inhibitor-related colitis with characteristic endoscopic findings of colonic pseudolipomatosis. It is important to perform endoscopy and histological evaluation to d...Continue Reading

References

Nov 1, 1985·American Journal of Clinical Pathology·D C SnoverS Hutton
Jan 1, 1996·International Journal of Colorectal Disease·G GagliardiI C Talbot
Nov 17, 2017·Virchows Archiv : an International Journal of Pathology·Naziheh AssarzadeganRobert A Anders
May 2, 2018·Internal Medicine·Masaya IwamuroHiroyuki Okada
May 3, 2018·Inflammatory Bowel Diseases·Yinghong WangAdi Diab
Mar 8, 2019·World Journal of Clinical Cases·Aniruddh SomMark C Mattar
Apr 30, 2019·Alimentary Pharmacology & Therapeutics·Andrew P WrightRyan W Stidham
Sep 29, 2019·World Journal of Gastrointestinal Pathophysiology·Tsutomu NishidaShiro Adachi
Apr 15, 2020·Clinical Colorectal Cancer·Tenglong TangYinghong Wang
May 19, 2020·British Journal of Cancer·Vincent Ting Fung CheungOliver Brain
Nov 6, 2020·Clinical Journal of Gastroenterology·Antonella GalloMassimo Montalto

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