A case of infantile acute lymphoblastic leukemia presenting with rearrangement of MLL at 11q23 and apparent insertion or translocation at 10p12

Cancer Genetics and Cytogenetics
C A TiradoB K Goodman

Abstract

We report the case of an 11-month-old patient with a clinical diagnosis of infantile acute lymphoblastic leukemia and an MLL (11q23) rearrangement in 69% of nuclei, revealed with interphase fluorescence in situ hybridization (FISH). Routine chromosome analysis of the bone marrow showed a very subtle rearrangement involving the short arm of chromosome 10 and the long arm of chromosome 11 in the abnormal cells. To clarify the nature of this rearrangement, we hybridized the MLL break-apart probe to previously G-banded slides. The rearrangement was interpreted as a small inversion within the band 11q23, separating the 5' MLL from the 3' MLL region. This segment on the long arm of chromosome 11 containing the rearranged MLL locus was either inserted in or translocated to the short arm of chromosome 10 at approximately band 10p12. The inversion affecting MLL may have followed insertion or preceded it. Molecular characterization of this rearrangement was not possible, due to limited sample material. There have been previous reports of rearrangements of MLL with the MLLT10 (alias AF10) gene locus at 10p12, including an interstitial inverted insertion of 11q13q23 in one case and insertion of 11q14q23 at 10p12 in another. These both resu...Continue Reading

References

Jan 1, 1996·Cancer Genetics and Cytogenetics·C SeccoE Paietta
Mar 25, 2000·Cancer Genetics and Cytogenetics·E J SinclairA E Watmore
Jul 20, 2002·Cancer Genetics and Cytogenetics·Patrice RollAnne-Marie Vagner-Capodano

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Citations

May 19, 2005·Cancer Genetics and Cytogenetics·Lydia ChristiansenDaynna J Wolff
May 14, 2008·Cancer Genetics and Cytogenetics·Gwendoline SolerRoland Berger
Oct 18, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Helena Santos-Rosa, Carlos Caldas
Sep 26, 2007·Human Molecular Genetics·Ahmad MiremadiCarlos Caldas

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