A Case of Influenza Associated Fulminant Myocarditis Successfully Treated with Intravenous Peramivir

Infection & chemotherapy
Seung Hee BaikMin Ja Kim

Abstract

We report the case of a patient with fulminant myocarditis caused by influenza A virus, who presented with acute-onset heart failure and cardiogenic shock and was treated successfully with single dose of intravenous peramivir and with pharmacologic hemodynamic support. A 45-year-old Korean woman presented to our emergency department (ED) with shortness of breath and an episode of seizure that developed abruptly 5 hours before she arrived in the ED. She had a history of recurrent epileptic seizure 25 years ago, but denied other specific medical illnesses. In the ED, she was hypoxemic (arterial partial pressure of oxygen, 59.8 mmHg on room air) and chest radiography revealed bilateral alveolar infiltrates. A rapid antigen test for influenza A virus was positive, and she was administered a single dose of peramivir (300 mg) intravenously. Five hours later, the patient's dyspnea had worsened and she was hypotensive (blood pressure, 86/53 mmHg), requiring norepinephrine infusion. Further evaluation disclosed an increased cardiac troponin I level of 1.36 ng/mL and a depressed left ventricular ejection fraction of 30%. Under the diagnosis of influenza A-associated myocarditis and cardiogenic shock, she was managed with continuous criti...Continue Reading

References

Jan 11, 2000·The American Journal of Forensic Medicine and Pathology·K B NolteS R Zaki
Sep 18, 2008·Nature Clinical Practice. Cardiovascular Medicine·Sachin GuptaPradeep Pa Mammen
Feb 21, 2009·Vaccine·Thijs Kuiken, Jeffery K Taubenberger
Nov 4, 2009·The New England Journal of Medicine·Debra Birnkrant, Edward Cox
Apr 23, 2010·Obstetrics and Gynecology·Vanessa Laibl RogersGeorge D Wendel
Mar 4, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jaime E HernandezUNKNOWN eIND Peramivir Investigators
Jan 1, 2010·BMJ Case Reports·Miguel CobasSi Pham
Mar 12, 2013·International Journal of Cardiology·Zahra Raisi Estabragh, Mamas A Mamas
Aug 30, 2013·Antiviral Therapy·Michael G IsonWilliam P Sheridan
Jan 17, 2014·Internal Medicine·Natsuko YoshimizuNobukazu Ishizaka

❮ Previous
Next ❯

Citations

Dec 27, 2019·The Journal of International Medical Research·Zhijun DongChunshan Luo
Apr 9, 2020·Frontiers in Cell and Developmental Biology·Ninaad LasradoJay Reddy
Oct 14, 2020·Nature Reviews. Cardiology·Carsten TschöpeSophie Van Linthout

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Related Concepts

Related Feeds

Cardiogenic Shock

Cardiogenic shock is a devastating consequence of acute myocardial infarction and is associated with an extremely high mortality. Here is the latest research.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.