A case of limited systemic sclerosis with p-ANCA, complicated by multiple cerebral hemorrhages.

Rheumatology International
Bharath Manu Akkara Veetil, Barry M Schimmer

Abstract

ANCA associated vasculitides are a group of disorders characterized by the presence of necrotizing inflammation of blood vessels that involve venules, capillaries, arterioles, arteries, and veins. They are characterized by the presence of antineutrophil cytoplasmic antibodies (ANCA). ANCA associated vasculitis commonly affects the kidney producing proteinuria, hematuria and variable degrees of renal failure. Other organs involved include the lung, skin and peripheral nervous system. We present a patient with limited systemic sclerosis, who later developed pauci-immune glomerulonephritis with p-ANCA (antimyeloperoxidase) specificity and, whose disease was later complicated by cerebral vasculitis with multiple intracerebral hemorrhages.

References

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Citations

Oct 27, 2010·International Journal of Rheumatology·Lily Kao, Cornelia Weyand
Feb 1, 2011·Seminars in Arthritis and Rheumatism·Uri AradOri Elkayam
Jul 6, 2014·Acta neurologica Belgica·Helena SaracKamelija Zarkovic
Jul 6, 2013·Seminars in Arthritis and Rheumatism·Tiago Nardi AmaralSimone Appenzeller
Nov 3, 2016·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·David BergeronRobert Laforce
Nov 17, 2017·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Sae ArataniShuichi Tsuruoka
Feb 16, 2019·Arthritis Research & Therapy·Jayne MoxeyMandana Nikpour
Nov 26, 2009·Current Opinion in Rheumatology

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