A case of malignant hyperthermia that was difficult to be differentiated from oral antipsychotic polypharmacy-associated neuroleptic malignant syndrome

JA Clinical Reports
Yoshiki HaraShigehito Sawamura

Abstract

Malignant hyperthermia (MH) occurred during anesthesia with volatile inhalation anesthetics in a patient under treatment with multiple oral antipsychotic drugs and with a history of multi-acting receptor-targeted antipsychotic drug (MARTA)-induced elevation of serum creatine kinase (CK). Since the patient was considered to be at high risk for neuroleptic malignant syndrome (NMS) based on this history, differential diagnosis between MH and NMS was difficult at the time of onset. Later, the patient was found to be predisposed to MH based on abnormal high rate of the Ca2+-induced Ca2+release (CICR). We concluded that MH was induced by the volatile inhalation anesthetics.

References

Aug 6, 2000·British Journal of Anaesthesia·P AdnetR Krivosic-Horber
May 4, 2004·The Journal of Clinical Psychiatry·Jambur AnanthTaghrid Sidhom
Mar 16, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J CairneyR Hawes
Jun 1, 2011·British Journal of Anaesthesia·P M Hopkins
Mar 28, 2013·Anaesthesia and Intensive Care·R TiruvoipatiM Bailey

❮ Previous
Next ❯

Citations

Jan 21, 2020·Journal of Perianesthesia Nursing : Official Journal of the American Society of PeriAnesthesia Nurses·Edwin N ArokeBryan A Wilbanks

❮ Previous
Next ❯

Methods Mentioned

BETA
sedation
biopsy

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Related Papers

Community Mental Health Journal
Margaret McDermottMarcy Traum
Nihon rinsho. Japanese journal of clinical medicine
Ikuko KishidaChiaki Kawanishi
© 2022 Meta ULC. All rights reserved