A case of malignant mastocytosis with near-haploid, near-diploid, and polyploid cells in the bone marrow

Cancer Genetics and Cytogenetics
M Bauchinger, J Mezger

Abstract

Chromosome analysis in bone marrow cells of a 41-year-old woman with malignant mastocytosis (MM) revealed near-haploid (59%), near-diploid (36%), and polyploid (5%) cells. Near-haploid cells had a mode of 25 chromosomes with variable disomy and nullisomy of particular chromosomes. Disomy for chromosome 19 and chromosome 20 were most common. A 17p+ marker was observed in all cells. Other structural chromosomal changes were dicentrics, ring chromosomes, translocations, and double minutes. The modal chromosome number in near-diploid cells was 46 with a range of 41-52. The majority of cells with 46 chromosomes were pseudodiploid and only a few had a normal female karyotype. As in near-haploid cells, various structural chromosomal changes were found. The 17p+ marker was also present in occasional cells suggesting a relationship between the two tumor cell populations. Chromosome numbers in polyploid cells ranged from 70 to about 600. Identical copies of dicentrics or markers were identified in some cells.

References

Oct 1, 1986·British Journal of Haematology·R DaltonS Eridani
Jan 1, 1988·Leukemia Research·J H ButterfieldG J Gleich
Jan 15, 1986·Cancer Genetics and Cytogenetics·U KristofferssonF Mitelman
Mar 15, 1985·Cancer Genetics and Cytogenetics·S MisawaJ R Testa
Aug 4, 1973·Lancet·O SanchezJ J Yunis
Feb 1, 1982·Cancer Genetics and Cytogenetics·P E Barker
Jul 1, 1984·Cell·R T Schimke
Jan 1, 1984·Annual Review of Biochemistry·G R Stark, G M Wahl

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Citations

Dec 1, 1994·Cancer Genetics and Cytogenetics·Y ZhangH Bartels
Apr 8, 1998·Cancer Genetics and Cytogenetics·D FlagielloB Dutrillaux
Feb 12, 1999·Cancer Genetics and Cytogenetics·R NogueraA Llombart-Bosch
Aug 16, 2000·Cancer Genetics and Cytogenetics·B SwolinG Roupe
Mar 22, 2001·The British Journal of Dermatology·L A FearfieldC B Bunker
Aug 12, 1999·British Journal of Haematology·B J Bain
Jan 18, 2018·Genes, Chromosomes & Cancer·Nicole NaumannAlice Fabarius

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